GFork

[suggestion] this likely goes beyond the scope of this script and it's really only a suggestion-light. i know greasy addons offer a menu function for settings.
maybe add a settings menu for

• a) big(ger) icon for not_interested function (as shown in the attached pic); that way i have an easier time aiming for the icon.
  
• b) hide/remove the 'remove channel' option (i rarely use this one so i hid it. i also only now noticed that all your script icons are handled by the same size declaration (i think). like i said, these are only light suggestions)
  -- b.1) i guess hiding the 'remove channel' is redundant if not_interested can be made bigger and put in a different place than REMOVE.

i'm fairly certain i've seen a monkey menu type that allows a toggle as sub-menu inside of the monkey panel and not create a separate panel @ 3rd segment of the attached pic vs. the 2nd segment (a separate settings panel; link to script https://greasyfork.org.cn/en/scripts/9165-auto-close-youtube-ads/code ).

You can use an extension like Stylus to override the placement, visibility, and size of the icons:

  .yt-one-click-dismiss[data-block="video"]:not(#\0) {
    width: 24px !important;
    height: 24px !important;
    border-width: 3px !important;
    &::after {
      border-width: 3px !important;
    }
  }
  .yt-one-click-dismiss[data-block="channel"]:not(#\0) {
    display: none!important;
  }

BTW, this can also be used as a userscript in your existing extension for userscripts.